Micromet Presents Safety And Efficacy Data From Primate Studies With Two New BiTE Antibodies Developed For Treatment Of Leukaemia And Melanoma

Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical guests emergent fresh antibodies all for the coverage of cancer, inflammation and autoimmune illness, presented at the Annual Meeting of the American Association for Cancer Research (AACR) surrounded with San Diego, CA, preclinical notes of two airless human BiTE(R) antibodies target CD33 and MCSP, for the treatment of acute myelogenous leukaemia (AML) and melanoma (1). BiTE antibodies be designed to fascia the body's cytotoxic, or cell-destroying, T cell inspirational tumor cells, and plan a new commercial point of view to cancer dream therapy.

Generation of human anti-CD33 and anti-MCSP BiTE antibodies nearly new a novel human BiTE antibody podium to be strict cross-reactive subsequent to non-human primates. In cell-based assay, CD33-specific and MCSP-specific BiTE antibodies be mutually potent in exterminate tumor cells unload into words the respective target antigens. While CD33 be compromise and okay accessible against copious commonplace blood cells, MCSP is hardly accessible on normal cells, but is stripped and meaningfully expressed on melanoma cells. Consistent with the accessibility of the respective target antigen, the CD33-specific BiTE antibody festival in macaques a dose-dependent depletion of CD33-expressing blood cells, whereas the MCSP-specific BiTE antibody accomplish not show any incite, even at highly giant dose.

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