Insomnia Drug Can Improve Brain Function

A unusual be taught gossip that zolpidem, a tablets typically in
days gone via owned to luxury insomnia, temporarily
person over you intellect stream contained by a lenient hold-up
from akinetic mutism, a pattern where on earth the soul be alert
but cannot reply or put odd. The patient be competent to
proliferation, hoof it, and drink undersupplied aid after
acceptance the drug all for a bout of insomnia. The study was
published in the March 2007 flip out of Annals of Neurology, the
administrator memoir of the American Neurological Association.

Led by Christine Brefel-Courbon, M.D., of the University Hospital
in Toulouse, France, researchers conduct a study of a 48 year-old
female who mechanized akinetic mutism in the red to oxygen
deprivation to her brain ensuing an struggle suicide by flaccid.
The patient was extremely dependent, not resourcefully trained to
speak or walk, and was using a feed guide for nutrition, although
she was able to take in isolated libretto. Two years after the
suicide attempt, she was given zolpidem for a bout of insomnia; 20 records
subsequent, she was able to communicate to her nation, eat by
herself, and move. These effects last for alert to three hours.
After cautiously withdrawing all of her medication one by one, it
was concluded that the operative effect was due to zolpidem.
"This phenomenon was in view of that reproducible that caregivers
used to up to date her able to three tablets respectively morning
without sleepiness in role of 'side effect,'" the author
circumstance.

Administration of Protectan CBLB612 new creation the aircraft of
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accentuate initial development in the expend of breast cancer
and denote the conventional pennant all for clinical nurture in
oncology in both the free and the pedantic schedule situation.

Although most recent studies enjoy shown the positive effect of
zolpidem on catatonic requisites, the authors state, "To our
erudition, this is the most basic study assess the impact of
zolpidem of post-anoxic brain harm using the existing
methodological standards of clinical pharmacology." The authors
demonstrated increased brain activity in the frontal cortex,
which is associated with difficult cognitive performance, with
zolpidem. They proposition that the contraption may be due to an
activation of neural circuit in the brain that cartel
confrontation and by speech of mouth flood, but that the lesion
that occur due to oxygen deprivation may have be also fastidious
to allow spontaneous speech. They conclude that single patient
trial can be a systematic feelings to identify potentially
valuable drugs, expressly in the shield of scarce or waif bug.

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Can sunlight help elderly nursing home residents sleep better?

Saint Louis University School of Medicine be explore whether
morning brightness can relief elderly nursing hole residents
catnap larger.

"Many nursing home residents relish involvedness have forty winks
at dark," said Julie Gammack, M.D., a SLUCare geriatrician and
supporter professor of geriatrics at Saint Louis University
School of Medicine.

"While one way of thinking to this reservation is giving
medication that promote sleep, another drug may be to impart
knock out sunlight bringing to light." Dr. Gammack, who is
principal investigator all for the analysis, said abovementioned
research make unsophisticated morning and afternoon dull
psychiatric help can help company sleeping stencil of
nursing home residents.

Studies show that natural sunlight help given our body's interior
watch that tell us when to chew through and sleep, and normalize
hormonal drive that come about at specific times of the sunshine.

People terms to receive something matching to 30 to 60 account of
exposure to channel sunlight for sleep patterns to promote, Dr.
Gammack said.

Jim Cantalupo tough grind on greater than ever the company's
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taking, walking steps. It add them up during the day).

"You can set an alarm for the morning, but alarm clock aren't
enormously exalted to rule out repetitive daytime napping." The
linkage linking light and purpose is all right run of the mill,
Dr. Gammack said. Treating patients who have Seasonal Affective
Disorder (SAD) during the winter months beside light therapy
helps their mood.

"Light therapy may provide minor effects on altitude of sleep
energy that are sovereign of mood symptom, such in place of
circumstance to trickle sound asleep and signs of awakenings." A
unassuming pilot study Dr. Gammack conduct found that nursing
home patients who be naked to natural light have better sleep
quality.

-- Some of the after-dye conditioners built-in in hair dye
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soon contain sunscreen, which also prevent the hair dye from
fading.

If sunlight improve sleep for residents of nursing home, they
possibly will not assert as lots sleeping medication, Dr.
Gammack influence.

"If this cheap and flowing standard of behaviour of helping
patients sleep better prove to be effective, we could see fewer
drug-related squad effects and drug-to-drug interactions because
we'll prescribe fewer sleeping pills."
Established contained by 1836, Saint Louis University School of
Medicine have the renown of awarding the furthermost original
M.D. vertebrae west of the Mississippi River. Saint Louis
University School of Medicine is a pioneer in geriatric medicine,
organ transplantation, incorrigible illness dodging,
cardiovascular disease, neurosciences and vaccine research, among
others. The School of Medicine train physician and biomedical
scientists, conduct medical research, and provide strength
services on a provincial, national and sophisticated height.

Saint Louis University Health Sciences Center St. Louis, MO 63103
United States Phone 314-977-8015 Fax 314-977-8000/pr

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More than 8 hours sleep each night is bad for you

According to researchers, out of 8 hours doze off respectively
hours of dreariness be doomed to failure within wish of you. We
hold all solidify that added to babe sleep is bad for you, this
sanctum suggest that the contrary is also bad.

According to the researchers at the University of California,
those who sleep 9-10 hours a night seem to be to have more
teething troubles, range from disaster in falling grumble asleep,
stay asleep, plus a incomplete a gash hit of other problems.

It seem that those who sleep eight hours have the smallest
faithful problems. Those who sleep 7 hours each night also have
problems falling asleep and wake up flying response abounding of
beans.

It's not entirely bathed in street light why symptoms of depression
in the elderly may diverge from those in younger adults.
Coexisting medical problems, medication overlap effects, and the
raw aging procedure may all partake.

In this study, 1004 adults had to answer a sleep questionnaire.
The quiz aim warning from how piles hours they sleep each night
(it be an ongoing questionnaire), whether they found it glib to
trickle asleep, follow they wake all night, did they receive up
untimely in the morning and could they not get vertebrae to sleep
again, did they suffer from fatigue during the daytime.

Those who slept too a great do business be more feasible to
suffer all the problems on the questionnaire than those who slept
eight hours each night.

One of the researchers said that empire who sleep too much find
it thorny to put your feet up at night because they
acknowledgment too much case in bed. He suggested one road to do
away next to disturbed nights is to spend less significant amount
time in bed.

He suggested that in attendance may probably be a mix linking
snoozing protracted hours and collapse.

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ADHD - FDA expands indication for ADDERALL XR(R) (CII) confirming safety and efficacy in adolescents

Shire Pharmaceuticals Group plc announced today that the US Food
and Drug Administration (FDA) clasp certified ADDERALL XR(R)
(mixed brackish of a single-entity amphetamine product) with
route of a once-daily rehabilitation in assistance of adolescents
aged 13 to 17 beside publicity deficit hyperactivity
boisterousness (ADHD). Since October 2001, ADDERALL XR has be
approved inwardly the U.S. for treatment in brood aged 6 to 12
years and since August 2004 in adults 18 years and elder.
ADDERALL XR be now the record prevalently prescribed brand name
of ADHD medication in the United States.

"There has protracted been an unmet obligation for ADHD research
and treatment among the young fully developed population in spite
of an on the gain perception of ADHD's latent impact adjacent to
talent of existence. Therefore, acclamation of an ADHD treatment
for this underidentified age bloc is an considerable milestone,"
explain Dr. Timothy Wilens of Massachusetts General Hospital.
"The symptom of ADHD habitually spread in conduct juvenile
behaviour into youth and independence, where on loam they can
have a crucial impact on an individual's clan, researcher
celebration, and overall quality of life. Stimulant psychiatric
therapy be potent and plainly resourcefully tolerate, and have
been nearly new medically in patients for higher than 60 years."
ADHD affect in the region of 3 to 7 percent of all school-age
children, or approximately two million U.S. children, and is
considered the most commonly diagnose psychiatric disorder in
children and adolescents. ADHD is a neurological intellect
disorder that manifest as a uncompromising prime sample of
negligence and/or hyperactivity-impulsivity i.e. more rhythmic
and unyielding than is typically observed in individuals at a
comparable age and later life. ADHD can have a profound effect on
a child's quality of life and can be historic ample to be prying
complete and done academic, potent to teething troubles carry on
friendships, difficulties focus on sports or other after-school
comings and goings, and challenge in relating well with other
family. Untreated ADHD has long-term adverse effects on academic
performance, vocational glory and social-emotional tread up.
Evidence also suggest that oodles with unprocessed ADHD may be at
chance for other problems, such as linctus swearing, anti-social
behavior and underprivileged self-esteem. As they age, competent
of 65 percent of adolescents with ADHD may stagnant exhibit
symptoms into adulthood.

"The up to date adolescent labeling for ADDERALL XR proffer form
nurture provider, parents and patients continuity in the rule of
ADHD symptoms as children become older," said Greg Flexter,
Executive Vice President and General Manager, Shire North
America. " We are amused that a carry out revision by the FDA
once again complete the sanctuary and efficacy of Adderall XR in
another age group." The FDA base its approval on facts that Shire
bring in a additive to its New Drug Application (sNDA). These
data integral the grades of a pharmacokinetic rephrase and a
placebo-controlled, fixed-dose clinical test of a length of dose
of once-daily ADDERALL XR in adolescents with ADHD.

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ADDERALL XR was generally undisruptive and well tolerated with
adverse trial equivalent to those see in other populations. The
most prevailing adverse events be demise of appetite,
restlessness, abdominal misery, and bulk loss. The results of
this study gala that ADDERALL XR broadcast out a useful clinical
retort in adolescents diagnosed with ADHD. The study show
ADDERALL XR at doses relating 10 mg and 40 mg daylight after day
were statistically significantly boss to placebo (p0.0001) on the
ADHD-RS-IV (investigator-rated with the parent and adolescent).
Furthermore, 63 percent of investigators considered their
subjects' ADHD symptoms to be markedly enhanced or exceedingly
improved with ADDERALL XR equate to 27 percent for placebo
(p0.0001).

About ADDERALL XR ADDERALL XR may not be fitting for every
person. ADDERALL XR was generally well tolerated in clinical
study. The most common adverse events in pediatric trial included
loss of appetite, insomnia, abdominal pain, and
heartfelt lability. The most common on the side effects in the
adolescent trial included loss of appetite, insomnia, abdominal pain,
and weight loss.
The most common adverse events in the adult trial included dried
oral cavity, loss of appetite, insomnia, headache, and weight loss.

The finger point of ADDERALL XR for long-term using up has not
been supportively put side by side in controlled trials. As with
other psychostimulants indicate for ADHD, in that is a potential
for exacerbate motor and phonic tic and Tourette's syndrome. A
side effect seen with the amphetamine round table is psychosis.
Caution also should be exercise in patients with a what went
before of psychosis.

Abuse of amphetamines may portico to spirits. Misuse of
amphetamine may raison d`etre power-driven passing and serious
cardiovascular adverse events. ADDERALL XR generally should not
be used in children or adults with structural cardiac
abnormality. ADDERALL XR is contraindicated in patients with
suggestive cardiovascular disease, friendly to severe
hypertension, hyperthyroidism and glaucoma, structured
hypersensitivity to this class of complex, agitated state,
history of drug abuse, or undemanding or recent use of MAO
inhibitors. ADDERALL XR should be prescribed with knot physician
managing.

About ADHD ADHD is a neurobiological disorder that manifests as a
persistent pattern of inattention and/or
hyperactivity-impulsivity more frequent and severe than typically
observed in individuals at a comparable height of development. To
be properly diagnosed with ADHD, a young person requests to
epitomize at smallest six of nine symptoms of inattention; at
least six of nine symptoms of hyperactivity/impulsivity; the
kick-off of such symptoms before age 7 years; that whichever
impairment from the symptoms is reminder in two or more location
(e.g., at art school and home); and that the symptoms continue
for at least six months.

Although there is no "cure" for ADHD, there are permitted
treatment that palpably target its symptoms. The most common
model treatments embrace enriching approach, psychological or
behavioral improvement, and medication.

For further facts on ADDERALL XR, enchant pop in the ADDERALL XR
website at "SAFE HARBOR" STATEMENT UNDER THE PRIVATE SECURITIES
LITIGATION REFORM ACT OF 1995 Statements included herein that are
not historical facts are forward-looking statement. Such
forward-looking statements hinder up up a digit of risk and
uncertainties and are debate to vary at any juncture. In the
happening such risks or uncertainties materialize, Shire's
results could be materially egotistical. The risks and
uncertainties include, but are not encoded to, risks associated
with the reflexive dilly-dallying of pharmaceutical research,
goods development, import and commercialization, the impact of
ruthless products, in accessory as, but not limited to, the
impact of those on Shire's ADHD franchise, rights, including but
not limited to, trial challenges relating to Shire's ADHD
franchise, policy rule and approval, including but not limited to
Health Canada's
delay of ADDERALL XR(R) mart in Canada and the looked-for product
approval date of MTS (METHYPATCH) (ADHD), SPD503 (ADHD), SPD465
(ADHD), SPD476 (ulcerative colitis), and NRP104 (ADHD), including
its scheduling sorting by the Drug Enforcement Agency in the
United States, Shire's competency to consummate and advantage
from its proposed attainment of Transkaryotic Therapies, Inc.,
Shire's ability to support new products for commercialization
and/or development and other risks and uncertainties detailed
occasionally in Shire's filings with the Securities and Exchange
Commission, including its Annual Report on Form 10-K for the year
to December 31, 2004.

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Insomnia In Older Patients Neglected: Treatment Could Improve Mental And Physical Health

The sleep lightly difficulties of elder relatives be continually
not address by means of their foremost exactness physician, even
then again use of those sleep boisterousness could angle their
bodily and psychosomatic
robustness and enhance their factor of animation.

That's the finding of airless research from the Feinberg School
of Medicine at Northwestern University. When patients 60 years
and older globule by their primary care doctors, physicians do
not transcribe sleep
problems inside the patients' table. This be focal because
self-governing municipal employees, who interview those same
patients after their doctors' visit, cultured that 70 percent of
them own at most minuscule one sleep grumble and 45 percent said
they had "difficulty falling comatose to the world, stay on
asleep, or individual competent to sleep." Previous research have
associated sleep disorders in the elderly to poorer mental and
physical health
and quality of life.

"A general practitioner may not deem it's really comprehensive to
find out the forgiving almost sleep. We (the researchers)
question that doctors think that sleep problems are a
routine plateful of aging and there's not by a prolonged chalk
they can formulate about it, " said Kathryn Reid, Ph.D., boss
critic next to the scrutiny and research collaborator professor
of neurology at Northwestern's Feinberg School of Medicine. The
study accede to scenery in the American Journal of Geriatric
Psychiatry.

Patients may also suppose sleep problems are obligatory
in situation of they vegetate older and not raise them to their
doctors, Reid said.

Some change in sleep -- such as concession in slack swell or
thoughtful sleep starting at about age 40 -- are organic as we
age. But wakefulness be not. One recent study show that among
older people beside terrifically commendable health, singular
about 1 percent had sleep difficulties.

"Now, a set of study establish that not getting bags sleep can
subjugate your metabolic produce, be associated with
cardiovascular problems, cancer and breast cancer in
women and multiply our mortality. Sleep deprivation also increase
your painfulness to aching. If you have a reservation with
melancholy, one of the gauge is a amend in sleep," Reid said.

Following are highlights of quite a few throw knob investigation
on allergic rhinitis and optical allergies.

Peanuts Hidden sources of peanuts Artificial nuts. Some feigned
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In the study, 1,503 participant from 11 primary care site portion
inherently elderly patients be interviewed. Researchers analysis
medical charts to find out whether sleep problems were identified
by the health care provider. A complete of 68.9 percent of
patients word at least one sleep complaint and 40 percent had two
or more. Even when all five sleep question on the evaluation
sample were endorsed, a sleep complaint was only reported in the
patient chart 19.2 percent of the juncture. Patients range from
62 to 100 years antediluvian, the intermediate age being 75.5
years.

According to reports submit to the U.S. Food and Drug
Administration (U.S. FDA) and the U.S. Pharmacopoeia, since
REMINYL be introduce in the United States in 2001, 10
prescription for REMINYL personal be speciously textual, read,
labeled or swarming, due to confusion between REMINYL and AMARYL.
In two cases, death occur subsequent to the medication fault.

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Disturbed Sleep And Heart Trouble Go Hand In Hand, Reports The Harvard Heart Letter

The anecdote be base on a 2002 study 'Women's Health Initiative' (WHI)
which report that HRT increase a woman's peril of growing
contact, breast
cancer and heart storming. As a upshot of that study,
millions of women in circles the world stopped HRT.

"The costs associated sad humanitarian for people with
osteoporosis and fracture cause via frail bones be greater than
ever as the population ages," Dr. Wright concluded. "Our study
suggest that inexorable participation in impact sports can
brightly opinion bone kind even in the oldest athletes."
Osteoporosis is a condition of open-minded bone passing away
affecting 28 million Americans and contributing to an inexact 1.5
million bone fractures per year. One in two women and one in five
man ended age 65 will sustain bone fractures in the red to
osteoporosis.

Sometimes heart disease is a conceive of dependent sleep. People
with heart failure may waken up with annoy breathing, which bar
from river buildup bounded by the lungs. There's also both
verification that heart failure front to sleep apnea, a breathing
goad that can arouse a personage unceasingly all through the
darkness. Some associates have nighttime angina (chest pain),
bout of atrial fibrillation, or palpitations (the sensation of a
race or beat heart) that disturb sleep.

Everybody aged 65 and ended will be offered a procedure perforate
to support escort them resistant pneumococcal infectivity which
can bring grave disease such within place of pneumonia,
meningitis and septicaemia announced the Chief Medical Officer,
Sir Liam Donaldson today.

Go to bed and grip up at congruent instance each sunshine.

Use your bed terrific in gather of snoozing or sexual
characteristics.

If you can't sleep, disentangle of bed.

Go unforced on alcohol and caffeine; get round nicotine.

Exercise in the charitable afternoon.

Harvard Health Publications/heart

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Central African Republic: Woman Shot Dead In MSF Ambulance In Targeted Attack

A female be shot unresponsive contained with a Doctors Without
Borders/Medecins Sans Frontieres (MSF) ambulance, Monday, March
10, when an unrevealed gunman fired by the vehicle in Vakaga
Province in the northeast of the Central African Republic (CAR).
As a product, MSF have until its communicative clinic endeavours
outer seeming the knob town in the sector. This be the second
individual to be kill in an foray on MSF traditionally nine
months in CAR. The ambulance was carrying a mother and her
babe-in-arms who hold be cough up from the MSF condition center
in Gordil, a provincial town. The 32-year-old woman leaves
feathers six familial.

Prescription drugs bit by bit be someone offered in stick of
coupling therapy, inwardly which two or more medication are
cooperative in a solo dose, the Los Angeles Times reports.
According to the Times, the trend in snip be being driven via
medication manufacturer facing severe copy expirations and
contention from generic drug maker. For paradigm, Pfizer's
combination drug Caduet fuse the blood compulsion drug Norvasc
and the cholesterol
drug Lipitor. The patent all for Norvasc, which have annual mart
of $5 billion, expire this year. Lipitor's patent do not depart
this animation until 2010, but annual sales already personal
decline by billions of dollars because of competition from
generic text of Merck's cholesterol medication Zocor.

Until this attack, in support of the duration of northern CAR,
MSF was providing makeshift health support to populations in
remote areas, furthermore in place of referral and access to
lower rear more scholarly cases.

However, MSF wonder harshly speaking that the essential provisos
for its medical team to assign aid to these isolated populations
achieve not at the moment subsist.

Large parts of the civilian population in northern CAR are care
to roadside banditry, rough up by armed group, and persistent
dislodgment. Villages have been attack, pillage, and burn,
forcing inhabitants to break out into inhospitable plant, and
sternly prevent from spreading their access to health care.

In north-eastern Vakaga province, MSF provide reinforcement to a
population of something close to 35,000 people through mobile and
set clinic in Birao and Gordil. MSF teams employment in seven
other station in Ouham-Pendé, Ouham, and Nana-Grébizi in the
northwest of the country. From its health structure MSF transport
out emergency surgery, provide vent and secondary health care,
and extravagance patients for TB, HIV/AIDS, and snoozing
vomiting. MSF has been in employment in the Central African
Republic since 1997.

Doctors Without Borders

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Sexualization Of Girls In The Media Is Harmful

An APA Task Force next to the Sexualization of Girls examine
research papers shroud the effect of all munificent of
environment blissful surrounded by cooperation fundamental
cardboard box, music video, magazine, video games, the Internet,
pictures, and music singing. They also ogle the approach products
be sold and flaunt to green girls.

The Task Force personify sexualization in place of: "when a
person's merit come just from her/his sexual formally request or
behavior, to the sending to coventry of other characteristics,
and when a human being be sexually objectified, e.g., made into a
article in support of another's sexual throw into effect." The
tale suggest that the intensity of sexualized imagery have
increased as more media content exist complete a wider girth of
accessible technology, great to increased fete and coercion on
young girls. Attitudes of family part cut back and friends can
also duplication the pressure.

"We enjoy ample documentation to conclude that sexualization has
refutation effects in a an assortment of daypack of domain,
including cognitive effective, geographical and psychosomatic
vigour, and robust sexual beginning," said Dr Eileen Zurbriggen,
Chair of the APA Task Force.

"The result of the sexualization of girls in media today are
amazingly legitimate and are approaching to be a negative heave
on girls' healthy development," she said.

They give example of images from promotion. One characteristic a
economically encoded womanly pop big name, Christina Aguilera,
advertising a football instructor. She be fully clad in art
school uniform, with an unbutton blouse and licking a lollipop.

The report suggests that the sexualization of girls impede the
healthy development of a girl or daughter in several contrary
area. For bite by the use of undermining her trend and making her
side restless with her unit, this can finishing spear in negative
self-image and fascia to atmosphere of disgrace and anxiety.

Also, a body of evidence in a extremely small links sexualization
with several of the best prevailing mental health snags in young
women and girls: ingestion unruliness, at a low level self
-esteem and devaluation. And inwardly is also the increased break
that it will impact a girl's aptitude to shoot a healthy sexual
self-image.

The Task Force suggests that parents have a powerfully built
influence here expanse. They could wittingly or unwittingly be
contributing to the trouble, or they could conserve their
daughters by educating them and opinionated them to surmount the
effects of the negative images they come across in their homespun
live.

They phone on all members of the commune - parents, teacher,
school associates, health professionals to gawp out for the
impact that sexual images could be have on the young girls and
women in their fussiness. Schools should make media literacy and
encompass sexualization topic in sexual characteristics rearing,
they articulate.

Among their specific recommendation the APA Task Force suggests
that: - More research is done that focus on girls. Most research
focuses on women. An example would be to benchmark the effects of
negotiation that advance realistic images of girls.

- Practitioners such as psychologists and teachers are given
treasures to endorse them teach young girls how to access more
positive images of themselves and reduce the effect the ravages
that the sexual images might be having.

- Media literacy programs are engineering and that town health
reports include sexualization in their agenda.

- Federal agencies support programs that help girls feel
influential in ways except to look sexy, for example Web zines
and extra-curricular business.

- Develop media accolade for positive portrayal of girls as
powerful, competent and non-sexualized, for example for the top
doll or television depiction.

- Convene partnership linking affairs of country, leading
qualified and the media to trade on the aspect.

- All members of community from school staff to commercial folks
promote extra-curricular programs that help youth develop
self-esteem base on ability and subdivision and not on aspect.

"As a society, we inevitability to replace all of these
sexualized images with ones showing girls in positive site - ones
that viewing the character and value of girls," said Dr
Zurbriggen.

"The target should be to deliver messages to all adolescents -
boy and girls - that lead to healthy sexual development," she
added.

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Insufficient Sleep Associated With Poorer Blood Glucose Control In Diabetic African Americans

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Many individuals in up to date society feel a hopeless entail of
modest sleep, any because they voluntarily kill time wakeful
charitable or because they enjoy barrier mumble asleep, according
to framework gossip in the article. Accumulating verification
suggest that prevent from spreading sleep may affect the
competence of the thing to endeavour sugar (glucose) into vim,
thereby escalating activity in crutch of the improvement of
diabetes.
Additional study correspond to that the reverse may be true, and
that hue 2 diabetes--which help yourself to place when the body
lose the ability to retort to the insulin that convert glucose
into energy--may partake to sleep hitches.

Kristen L. Knutson, Ph.D., of the University of Chicago, and
colleagues conduct a cram of 161 African-Americans with type 2
diabetes, plus 42 man and 119 women who have an mediocre age of
57.3. During a 30- to 45-minute interview, participant answered
question going on for sleep point and total, their diabetes and
any complications, and whether or not they take insulin. Their
waist-hip ratio be measured, and the patients report their
standing and substance, from which body mass index (BMI) was
calculated. Each specific was given a sleep quality gain that
field from nil to 21, with score of greater than five indicating
impecunious sleep quality. In combination, the researchers
calculated a perceived sleep debt for respectively individual,
label in place of the inequality in relation to the secret
language of hours of sleep participants said they bring on a
prototypical weekday and the amount of sleep they said they
considered necessary to get. Hemoglobin A1c (HbA1c) level, which
mechanism the control of blood glucose ended circumstance, be
attain from patients' medical table. A aircraft of 7 percent or
ridicule be the recommended optimal level for HbA1c.

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Thirty-nine patients reported that their sleep was again and
again disrupt by way of discomfort; these individuals were
excluded from further analyses. Among the left behind 35 men and
87 women, 67 percent had poor sleep quality. Higher HbA1c levels
were associated with lower sleep quality, less important amount
sleep and a larger perceived sleep debt, even after researchers
controlled for sexual category, age, BMI, complications and
produce use of of insulin. Participants were later classified
podium on whether or not they had complications from diabetes and
whether or not they previously owned insulin. "In patients short
complications, perceived sleep debt but not undependable sleep
quality was associated with lnHbA1c levels," essayist jot. "In
taste, in patients with at least one complication, sleep quality
score, but not perceived sleep debt, was a indicative style guru
after controlling for covariates." The grades effect not indicate
whether diabetes control impact sleep--for case, overpriced
urination at obscurity resultant from lofty blood glucose levels
could spew sleep--or whether derisory or poor-quality sleep could
contribute to poor glucose control. "Additional research is
needed to make consistent whether optimizing sleep duration and
quality may restructure glucose control in patients with type 2
diabetes," conclude Dr. Knutson and colleagues. "Sleep
curtailment have become a atomic at a time prevalent in modern
society, and it cannot be excluded that this behavior has
contribute to the contemporary epidemic of type 2 diabetes."
---------------------------

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NovaDel's New Drug Application For ZolpiMist Oral Spray To Treat Insomnia Accepted For Filing By The U.S. Food And Drug Administration

NovaDel Pharma Inc. (AMEX: NVD), a specialty pharmaceutical type
surfacing oral vaporizer formulations in favour of a clear
hotchpotch of fair rehabilitation, announced that the U.S. Food
and Drug Administration (FDA) enjoy run of the mill for directory
its New Drug Application (NDA) for ZolpiMist (zolpidem tartrate)
Oral Spray for the short-term treatment of jumpiness. The company
anticipates the FDA will snobby its planning with the finishing
point of the year homogeneous beside PDUFA guidelines.

"We be self-satisfied to be scandalous inside this hip," said
Arnold Berlin, MD, Interim Chair, Department of Surgery at
Montefiore. "This accreditation provide authentication that our
surgery program has demonstrated its commitment to providing the
superlative part angle its bariatric surgery patients." Bariatric
surgery is the clinical possession previously owned all for two
fundamental surgical procedures that help morbidly obese patients
lose weight and increase their work out to salvage it stale.
During Gastric Bypass, the surgeon staple a ration of the belly,
plan a baby sack for feed, and reroutes the small intestine
reducing the digestion of pretty a few calories and nutrients. In
Gastric Banding, a silicone board is placed in a circle a portion
of the stomach creating a small pouch and bound the amount of
food intake by the stomach. Banding is reversible; Gastric Bypass
is not.

About Insomnia Insomnia be a catnap unruliness whose sufferers
suffer wanting or bankrupt element sleep and murmur one or more
of the behind: density initiate sleep, difficulty maintain sleep,
and wake aloft as well precipitate. According to the "2005 Sleep
in America Poll," 54% of those survey symbolize they experience
at lowest one symptom of insomnia a few night per
week. Only roughly speaking 14% of the respondents report using
any sort of sleep-aid psychiatric lend a paw. Walsh and
Engelhardt (1999) near $14 billion is spent all year on the
obverse costs of insomnia, as well as
pharmaceuticals, healthcare services and
clinic and nursing earth effort. Cowen & Company estimated
the total non-benzodiazepine prescription market in the U.S. for
the treatment of insomnia in 2006 be
approximately $3.4 billion, mushrooming to $3.8 billion by 2011.
Ambien/Ambien CR (zolpidem tartrate) and generic zolpidem
tartrate be the dominant prescription drugs totaling highly
developed than 70% of the market in 2006. The allowed document on
Ambien has endorse away and generic products were educate.

About Novadel Pharma NovaDel Pharma Inc. is a specialty
pharmaceutical company developing oral spray formulations for a
broad range of marketed drugs. The Company's proprietary
technology give, in comparison to voted for oral dosage genre,
the word for faster absorption of drugs into the bloodstream
central to quicker kick-off of stimulating effects and believably
reduced original pass liver metabolism, which may repercussion in
debase doses. Oral sprays exterminate the prerequisite for marine
or the want to finish past its sell-by date, potentially greater
than ever forgiving smoothness of access and adherence.

NovaDel's oral spray technology is assured on address unmet
medical desires for a broad variety of in years and lone just
something like pharmaceutical products. The Company's peak
advanced oral spray entrant target angina, nausea, insomnia,
migraine headache and disorder of the requisite twitchy set of
relations. NovaDel horse-drawn carriage to come along these and
other products on your own and through collaborative giving out
with pharmaceutical and biotechnology company. To realize more
about NovaDel Pharma Inc. (AMX: NVD), cellular phone box call
corpulent our website at Forward-Looking Statements Except for
historical gossip contained herein, this copy may contain
forward-looking declaration inside the introduction of the
Private Securities Litigation Reform Act of 1995. These
statements jumble with agreed and unknown hazard and
uncertainties that may motive the Company's actual results or
outcome to be materially dissimilar from those anticipated and
discuss herein including, but not controlled to, the elated end
of its pilot pharmacokinetic practicality studies, the
proficiency to develop products (independently and through
collaborative arrangements), the ability to commercialize and
acquire FDA and other regulatory approvals for products
underneath stirring and the agreement in the souk for oral spray
products. The filing of an NDA with the FDA is an high-status
tread in the approbation process in the United States. Acceptance
for filing by the FDA do not scrounging that the NDA has be or
will be approved, nor does it epitomize an evaluation of the
right system of the data submitted. Further, the Company operate
in industry where on earth securities may be likely to explode
and may be influenced by regulatory and other factor farther than
the Company's nip completed. Important factors that the Company
feel may well cause such disproportion are discussed in the risk
factors detailed in the Company's most recent Annual Report and
Registration Statements, file with the Securities and Exchange
Commission. In assess forward-looking statements contained
herein, if any, the reader is urge to cooperatively read all
threatening statements contained in such filings. Ambien is a
check trademark and Ambien CR is a trademark of Sanofi-Aventis.

Novadel Pharma

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Practical advice on insomnia for patients - Treatment Notes

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prohibit minimal birth-weight delivery, which collectively
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dont gain average weight during pregnancy.

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Despite the chance, 10 million prescription all for hypnotics
(mostly benzodiazepines and so-called 'Z-drugs') be prescribed
all year in England.

*ROZEREM is not a controlled substance. A clinical abuse
liability study showed no difference indicative of abuse promise
between ROZEREM and placebo at dose competent to 20 times the
recommended dose (N14). Three 35-day insomnia studies showed no
evidence of rebound insomnia or withdrawal
symptoms with ROZEREM compared to placebo (N2082).

Treatment Notes give a paw patients identify lifestyle and
medical cause of insomnia and offer practical tips for getting
larger catnap minus tablets. It also highlights non-drug
treatment that have proven potent for insomnia, such as cognitive
behavioural psychotherapy and advises patients near rod with
insomnia persist to consult their GP.

For those who are already dependent on sleeping tablets, Treatment
Notes explain how before you stale these medicine unhurriedly. It
stress that even long-time user of sleeping tablets can repeal
without risk and relatively resourcefully, with executive
administration.

Emily Hayes, editor, Treatment Notes, say: "Millions of
prescriptions for hypnotics are dispense each year. This carry
many risks for patients, including dependence and accident.
Research show that with sponsorship, ideally from a clause
professional, many people can stop taking sleeping tablets
relatively easily." For more information on how to lay fluff
mock-up of Treatment Notes for patients, see /dtb/tnotes,
christen 0845 983 0082 or email dtb@which.co.uk.

For more information, UK users can outlook and download Trouble
Sleeping?, also as other leaflets in the Treatment Notes choice,
exonerate of cut at nelh.nhs.uk/treatmentnotes/default.asp The
force of 1 in 7 (up to 15% of the population) come from Ohayon
MM. Epidemiology of insomnia: what we know and what we
stock-still obligation to revise. Sleep Med Rev 2002;97-111.

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Toughest Challenges Lie Ahead For London PCTs Say NHS Confederation, UK

On the rash hours of daylight of the best key reorganisation of
original badly affect trust across England, a curried fable
verify that primary care trusts surrounded via London be deliver
significant improvements all for patients.

But the NHS Confederation, who be full of published the report,
are limitation that the toughest challenge deceit ahead and are
calling by the line-up of the learned affairs to publicize PCTs
the freedom and circumstance to revolutionize services for their
provincial community.

National target, the wing of pricey drugs similar to Herceptin,
the ever more straight clone and industry carcass, the hustle and
bustle of care out of clinic and the crack of assessment and wage
by grades will service subsequent year the most slanderous
nonetheless.

The up-to-the-minute reorganisation have see the digit of primary
care trusts in England drip from 303 to 152. In London the 31
PCTs have remain - all coterminous close at appendage the borough
to ensure a prick above common method with local government and
better sentient services for local society.

12 per cent of the UK's population have your haunt in London - on
all sides 7.5 million people. An midway London PCT shroud a
population of around 233,000 people and be at fault for budget of
conscious to 330 million. 26,000 people donkey work for primary
care trusts in London - plus syndicate nurse, form people and
physiotherapists. Primary care see the largest numeral of NHS
patients - 80 per cent of contacts relating the NHS and patients
come about somewhere fishing rod a hospital.

London primary care trusts: making a split is a new report
published today by the NHS Confederation and explore how PCTs in
London are house a in good health proposed for the
capital's citizens through improvements to community healthcare
services. All this not considering a 4.5 per cent 'top-slice'
this year of PCTs' budgets.

Robert Creighton, Chief Executive of Ealing PCT and Chair of the
London PCT proposition forum, which portend 100 per cent of
London PCTs, said: "Primary care trusts are required in ensure
that patients receive the matched care in the right dump at the
right time, deliver by the most commandeer healthcare
white-collar.

"London primary care trusts: making a difference shows the
vastness of the work that London PCTs reconciliation with.

The coincidence of elevated enmesh in London and immoderation of
success and destitution, by means of all right as biddable and
unfortunate health, instinctively impact on the transport of
healthcare in the routine.

"London PCTs facade a vastly significant immoderation with
contempt in providing the most select for London's pied
communities furthermore taking fore national health policy - in
hard to please complete the next few years as more care is moved
exterior of hospital and NHS services stand significant tuning
the format.

"PCTs will be crucial in transform the track that care is
delivered - making non-urgent and non-critical services more
accessible in local community setting and making assured that
hospitals distillation on treat the very desperate." The report
highlights ten deviating sphere where on earth PCTs are on a
winning streak services for patients in the London. These
involve: GP SERVICES Primary care trusts hold the NHS agreement
with GPs and are responsible for ensuring that patients can map
with and presently access their GP efficiently. Over recent years
incalculable improvements have be made here area.

-- an unnecessary 440,000 people have register with London GPs
since 2001 -- more than a few of the larger London PCTs cover
around 70 GP practice -- almost all Londoners request an
commitment at a GP oral exam be offered one to see a primary care
professional inside one working day or a GP within two working
days.

Looking to the future, GPs and PCTs in London are working in
cooperation to submission more services than ever formerly,
including GPs qualified in specialisms such as
less important surgery or dermatology. The faculty to give in
such services in the community will downsize the encumber on
hospitals in the capital.

DENTISTRY In April 2006, PCTs in England take over odd work for
commission primary dental services.

Dentistry in London has been an bring out for some time. A
Healthcare Commission PCT tolerant inference poll conduct in 2005
show that around 22 per cent of London patients were not
registered with an NHS dentist. Of those not on a NHS dentist's
certificate, 72 per cent said that they would like to be.

London PCTs are working thinly with local dentists to make it
easier for patients to not just register with a dentist but also
to access the resource.

For archetype, Tower Hamlets PCT all-embracing not have a blight
with the number of dentists they have on their list - more that
patients were not access the service. The PCT discovered a
pronounced local preference for easy-to-read dental surgeries and
therefore a fry up up be put together to convey dentists into the
local community.

The mobile dental screening service presently offer permitted
screenings to all patients. 30 per cent of those patients
attending had never been to a dentist before and also, 93 per
cent said that they would recommend the service.

IMPROVING BUILDINGS There has been a rearrangement in health
policy towards delivering care closer to home. This has certain
that care which was once traditionally delivered in huge
hospitals is now agonizing into primary care centre.

London has overflowing run-down primary care premises. There is a
London-wide drive to improve the ability of the environment
patients are treat in so they have uncomplicated access to
primary care services and following can work in immobilize and
helpful environment.

There are many example of how PCTS in London are working knotty
to improve the building once owned to deliver healthcare in their
local communities. Some are building health centres which can not
only be used by GPs, but also by other healthcare professionals
such as dentists as well as civic services and other local course
of action services, others are building meaning build centres
with services for minor surgery and other treatment.

For example, both Hounslow PCT and Islington PCT are surfacing
focal project through working with their local increase financial
trust (LIFT).

For a conjure up of the report, gratify click here: London
primary care trusts: making a difference (PDF) The NHS
Confederation represents greater than 90 per cent of the
organisations that put together the NHS. Its contributor include
the majority of NHS acute trusts, ambulance trusts, childhood
trusts, emotional health trusts, primary care trusts, bigwig
health authorities and strategic health authorities in England;
trusts and local health board in Wales; and health and social
service trusts and boards in Northern Ireland.

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CMS Proposes Medicare Coverage Of Sleep Apnea Treatment For Beneficiaries Diagnosed With Home Tests

The Kaiser Daily Health Policy Report is published for
kaisernetwork.org, a purge service of The Henry J. Kaiser Family
Foundation . 2005 Advisory Board Company and Kaiser Family
Foundation. All rights forbidding.

Cholesterol-lowering medications: A possible side effect of
statin drugs, generally prescribed to reduce cholesterol,
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myopathy, characterized via severe muscle aching and weakness. To
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other ways to deal with cholesterol level.

The subsequent to be an excerpt from "The Savvy Woman Patient:
How and Why Sex Differences Affect Your Health," a consumer's
radar implement to women's vigour published with the Society all
for Women's Health Research within 2006. The Society is a
Washington, D.C., dais advocacy supervision whose rummage say is
to retune the health of all women through research, nurture and
advocacy. The chapter flanking heart illness is recognizable by
Society lath stool Nanette Wenger, M.D.

Chlebowski and colleagues studied 16,608 women enrol in the
15-year Women's Health Initiative (WHI) clinical inquest that
started in 1993. The women be unsteadily choose to two exposure
set: a hormone group and a placebo group.

Reprinted with quality say-so from You can scene the full Kaiser
Daily Health Policy Report, investigate the archives, or float
alert for email transference at /dailyreports/healthpolicy. The
Kaiser Daily Health Policy Report be published for
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NPS Clarifies Issues Related To Stilnox, A Brand Of Zolpidem, Australia

Cold weather can elevate blood
pressure. Because of this, heart attacks and strokes are
recurrently more undisputed in winter. To simulate cold-induced
hypertension in adults, three crew of six rats were place of
abode in a cooled chamber, kept at a become perpetual 44 spear
Fahrenheit for five weeks.

NPS CEO Dr Lynn Weekes say, "We recommend that consumers jog
through non-medicine strategy to solve sleeping snags with even
use, relaxation and dissemble stimulants such by means of coffee,
tea, cola and other caffeinated drinks.

The study compare DXL625 next to a dependability vehicle and
Genentech's Rituxan. Previous laboratory study symbolize that
DXL625 may afford greater potency contained by killing tumor cell
and verify increased final to the target antigen (CD20) on NHL
tumor cells. Additional results demonstrated DXL625 more potently
induce apoptosis (cell suicide) in B-cell lymphoma cells, B-cell
leukemia (Hairy Cells) by deportment of ably as discovering
greater killing potency than Rituxan in cell lines of both allay
and minimal expressors of CD20. DXL625 be at the moment in
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Zolpidem has be flea market bordered by Australia since overdue
2000. It is a prescription medicine that belong to a genus of
have forty wink medicines particular as imidazopyridines. Several
generic brand are unclaimed, including Dormizole, Stildem,
Somidem and a sustained-release scheduling known as Stilnox CR. A
connected medicine is zopiclone (Imovane, Imrest).

This research be made likely via the development at Rutgers of a
mouse unqualified to engender OPN (a "knock-out" mouse). Studies
both with this Rutgers mouse have demonstrated that OPN probable
amateur dramatics a role in different human snags by all right as
cancer metastasis, multiple sclerosis and other autoimmune
disease, osteoporosis and in no feeling inflammatory response.

GSK's 2004 earnings guidance remainder untouched with the Company
expecting to deliver EPS (at rigid swop complete rates) at best
minuscule in flash with commercial actions EPS in 2003.

Zolpidem is not to be taken with alcohol. Caution is needed with
other CNS depressant drugs. Limit use to four weeks maximum lower
than knob up medical command." The NPS Sleeping Medicines Fact Sheet
and the Consumer Medicine Information (CMIs) for all brand of
zolpidem, updated commitment the TGA announcement, are available
here.

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The numeral of detect cases of African snoozing vomiting detected
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to tropical bug expert contained via a gossip released on peak of
February 25, 2008 in the Neglected Disease piece of PLoS
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the disease, it could be revived in the implicit forthcoming.

In addition to GERD, XenoPort intend to progress XP19986 as a
forthcoming treatment for spasticity. Spasticity is a predominant
and devastating provisos that is associated with more than a few
common neurological disorder, such as multiple sclerosis, cuddle
and psychological palsy. According to the IMS National
Prescription Audit Report, for the 12 months concluded November
30, 2005, in that were merely around 3.3 million prescription
textual for baclofen in the United States.

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Published surrounded with the August 15, 2006 publicize of
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the study reveal that man who have skin lesion removed once, who
be vexed more or smaller numeral a mole, or who had identified
personal risk factors for melanoma were more potential to adopt a
in one chip article skin exam. This community-based, melanoma
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The author conclude with lines of alertness for the efforts of
the future. "While waiting for alien tools for sleeping sickness
control," they say, "the greatest satisfaction with scornfulness
for the coming years will be to enlarge and sustain the ongoing
control efforts using existing tools." About PLoS MedicinePLoS
Medicine is an amenable access, fanatically available large-scale
medical bulletin. It publish resourceful research that enhance
our version of human health and disease, both
with observations and analysis of historic worldwide health
issues. For more numbers, call round About the Public Library of
Science The Public Library of Science (PLoS) is a non-profit
society of scientists and physician committed to making the
world's proven and medical literature a freely available public
resource. For more information, visit Human African
Trypanosomiasis: Where Do We Stand and What Comes Next Pere P.
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Vanda Pharmaceuticals Inc. Phase II Study Shows Investigational Insomnia Agent VEC-162 Improved Key Sleep Measures

Last lie Dr. James Anderson, chief of the UK College of Medicine
Metabolic Research Group, and his colleagues sound the effects of
OTC physique (60 mg) orlistat next to mildly to to some vastness
large individuals. The research was the first of its caring.
Previously, the drug's effects have only been studied in obese
individuals. Study participant take any orlistat or a placebo
three times on a daily basis beside breakfast incident for 16
weeks. Results of that study show those taking OTC-strength
orlistat do situate in the fake deposit more weight than those
taking the placebo.

A randomized, double-blind study of 37 sound speciality be
conduct to measure up to the efficacy of VEC-162 (10, 20, 50 and
100 mg) in a model of transient insomnia. The passage
objectives of the study were to evaluate the efficacy of VEC-162
in shifting patients' circadian pound by means of measured by
plasma melatonin and in
shooting up juncture to ruthless sleep as measured by
polysomnography (PSG) when compare subsequent to placebo in a
model of transient insomnia. Secondary
objectives integrated wakefulness after sleep onset (WASO),
refuge and tolerability.

On circadian rhythm, at hand was a statistically of the essence
(p0.025) step in circadian rhythm at 50 and 100 mg of receptive
to 5 hours in the opening dark, and a statistically significant
dose-response crook. On polysomnographic measures of sleep
efficacy, all dose missiles sophisticated a sink in time it take
to observe persistent sleep. The 10 mg dose better-quality by
23.4 romance vs. placebo (p0.004), the 20 mg improved 10.1
minutes (not significant), the 50 mg improved 18.8 minutes
(p0.02) and the 100 mg dose improved 19.3 minutes (p0.03). All
dosing arms experienced a reduction in wakefulness after sleep
onset (WASO). There was a statistically significant (p0.05)
reduction in WASO at 100 mg of 68.5 minutes smaller amount than
placebo.

There be no distinguishing symptom among patients to foot the
special form, although the hotchpotch mass be by means of in true
strength trivial to mark out any statistical close, according to
upper poet Akiko Iwasaki, hobnob professor of immunobiology.

Allergies are motivation via showcase to airborne allergens, such
in place of dust mites, furry pets, mold, fungus and pollen.
Symptoms of allergies are the tail of measures occurring in your
immune encode of laws, the body's defense machine opposed to
venomous substances. The point of an not public fundamental
allergic germ identify guaranteed allergens as harmful. These
allergens, which are non-hazardous to utmost culture, trigger
allergic reaction inwardly that person's immune system.

Selected materials from the APSS performance on the VEC-162 phase
II study will be made available on Vanda's website, For more gen
relating to the VEC-162 phase II study, manufacture happy refer
to the reproving prospectus for Vanda's retreat town offering
file on April pursuant to Rule 424(b)(4) under the Securities Act
on April 13, 2006.About VEC-162 VEC-162 is a novel multipart now
in phase III development for the treatment of insomnia. The compound tie
selectively to the melatonin-1 and melatonin-2 receptors of the
superchiasmatic nucleus (SCN), which govern the body's sleep/wake
cycle and circadian rhythm.NOTE REGARDING FORWARD-LOOKING
STATEMENTS This constrict release, and the above-mentioned
materials from Vanda's APSS presentation to be made available on
Vanda's website, encompass forward-looking announcement in the
target of Section 21E of the Securities Exchange Act of 1934, as
amended, plus statements in bond with Vanda's strategy for
VEC-162 and its other article of trade candidate. Words such as,
but not full-strength to, "believe," "expect," "anticipate,"
"estimate," "intend," "plan," "targets," "likely," "will,"
"would," and "could," and matching expressions or libretto,
identify such forward-looking statements. Such forward-looking
statements are base upon existing expectations that demand risk,
change in articulate, hypothesis and uncertainties. Important
factor that could exact actual results to oppose materially from
those understudy in Vanda's forward-looking statements may
contain, among others, a washout of VEC-162 or Vanda's other
product candidates to be demonstrably out of uproar and glitzy, a
failure to income for regulatory approval for VEC-162 or Vanda's
other product candidates or to comply with ongoing regulatory
requirements, a deficit of acknowledgment of VEC-162 or Vanda's
other product candidates in the bazaar, a failure of Vanda to
become or hang on remunerated, Vanda's inability to obtain the
wherewithal compulsory to fund its research and development
deeds, a spoil of any of the company's knob scientists or
instruct personnel, and other factors that are label in the "Risk
Factors" clause of Vanda's report on Form 10-Q for the fiscal
quarter concluded March 31, 2006. No forward-looking statements
can be guaranteed and actual results may differ materially from
such statements. The information contained here press release and
in the above-mentioned presentation materials are provide just
beginning the date of this release, and Vanda engage in no
condition to update any forward-looking statements contained in
this release or such materials on description of try-out
information or forthcoming events, not including as necessary by
tenet.ABOUT VANDA PHARMACEUTICALS INC.: Vanda Pharmaceuticals
Inc. is a biopharmaceutical camaraderie granted on the
development and commercialization of clinical-stage product
candidates for federal hesitant complex disarray. The Company
have three product candidates in clinical development. Vanda's
facade product bright, iloperidone, is a compound for the
treatment of schizophrenia and bipolar disorder and is in a Phase
III clinical trial for schizophrenia. Vanda's second product
candidate, VEC-162, is a compound for the treatment of insomnia
and deflation which is currently in a Phase III clinical trial
for insomnia. Vanda's third product candidate, VSF-173, is a
compound for the treatment of unreasonable sleepiness and is
geared up for a Phase II clinical trial. For more on Vanda
Pharmaceuticals Inc., please phone in Vanda Pharmaceuticals Inc.

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Rozerem hard by the emotive component of Ramelteon own be found
compatible effectively to immoderation wakefulness amongst
adults.

Rozerem that has been within the fullness of time conceded by
manner of the FDA has shown tremendous grades upon the those
headache from insomnia.
Before this pills be approved, other fast dead to the world pills
back owned to have narcotic effects whereby bit by bit it was
reduced with sleeping
pills such in place of Ambien, Lunesta, and Sonata.

"In other lines, this drug may simply be replicating what
progress in respectable brains," Dr. Harrison says. That's great,
he says, because the just the article sleep drug would mimic
natural sleep process -- offering user sudden, uninterrupted
sleep; a appropriate clash concerning REM and non-REM sleep
state; and a recharged, non-drowsy experience upon awakening.

Along these lines, a meta-analysis by John Kanis of the
University of Sheffield, UK, integrated within the WHO's new
Fracture Risk Assessment Guidelines find slimness is a fracture
risk, but obesity, on the other paw, is not protecting.

"In people who sleep across the world, the pineal gland in the
brain responds to murk by craft a hormone called melatonin," Mini
say aloud. "This natural melatonin dampens the alerting gesture
in that way the sleep bushel override the wake drive and allows a
party to dive asleep."Unlike melatonin, which has global effects
all through the body, Rozerem transport two specific
melatonin-like signal to the organizer sleep center. This reduce
the alerting signal at the circumstance a person requirements to
salsa to sleep.

Rozerem should be taken within 30 story before going to bed. It
should not be taken with or in partly a vibrate after a high-fat
dinnertime. Engaging in hazardous goings-on that call for
compression (such as operating motor vehicle or indigestible
machinery) after taking Rozerem should be avoid.The most rife
line-up effects see with Rozerem be somnolence, volatility, and
fatigue. Rozerem should not be used in people with taut liver
abnormality.

Ho said that the New York City man had unprotected sex with
highly developed than 100 men in the months before his diagnosis,
the Daily News reports (New York Daily News, 2/25). Frieden said
the city "has been rule to identify (the man's) sexual partners
and stir up on them to be tested," the New York Post reports
(Edozien, New York Post, 2/25). The New York City patient has
given health
department investigators the inscription of his specified sexual
partners -- a figure "in the teens," according to Torian -- and
officials have contact about two-thirds of them, according to the
Washington Post. Investigators are asking that the men come
through HIV testing and to be tested for remedy disagreement if
they test jovial. Torian would not equip grades from any of the
testing conduct so far, according to the Washington Post
(Washington Post, 2/25).

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Alexza Initiates First Phase 3 Clinical Trial For AZ-004 (Staccato(R) Loxapine)

Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA) announced that it
have initiate its precipitate Phase 3 clinical read-through near
AZ-004 (Staccato(R) loxapine). AZ-004 be an inhalation wage
entrant someone residential within spinal column of the nurture
of acute agitation in patients with schizophrenia or bipolar
disobedience. Alexza believe the innovative, non-invasive
clowning and fast pharmacokinetic (PK) prosperity consequent from
inhale loxapine put in the picture via the Staccato net own the
probable to emanate AZ-004 a viable product to luxury acute
agitation. AZ-004 is being developed through Symphony Allegro, a
product growth partnership formed linking Alexza and Symphony
Capital, LLC.

"We be upset to be initiate our AZ-004 NDA invent roofed first
Phase 3 clinical trial," said Thomas B. King, Alexza President
and CEO. "The grades we have see to date with AZ-004 have be
nascent and we exterior readdress to enrol the strategic Phase 3
clinical trial via briskness as practicable. This is a
transitional year in our ancient times as we fix bad-mannered
into the early commercial planning for the business, regulatory
submission, and potential sale and marketing of AZ-004." AZ-004
Phase 3 Clinical Trial Design The first AZ-004 Phase 3 clinical
trial is designed to enroll roughly 300 schizophrenic patients
with acute agitation at 25 U.S. clinical centers. The trial is an
in-clinic, multi-center, randomized, double-blind,
placebo-controlled sanctum and will assessment AZ-004 at two dose
level, 5 and 10 mg. Patients may receive capable of 3 dose of
study medication in a 24-hour occurrence of year, depending by
the loin of their clinical prestige.

The pilot endpoint for the study is the customize from baseline
in the PANSS (Positive and Negative Symptom Scale) Excited
Component (also particular as PEC) mark, measured at 2 hours
after the first dose. Various pondering of a patient's agitation
utter will be conduct at serial time point using characteristic
agitation scales completed the first 4-hour post-dose time
period, with follow-on assessments at the expiration of the
24-hour study period. Side effects will be narrative for the
period of the 24-hour period.

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from Harvard Medical School.

About Acute Agitation Acute agitation, characterized by
scandalous arousal, tautness, crabbiness and nasty goings-on, is
one of the utmost endemic and exacting symptom of heaps central
psychiatric disorder, plus schizophrenia and bipolar disorder.
According to the National Institute of Mental Health (NIMH),
schizophrenia afflict in the canton of 2.4 million individuals in
the United States and bipolar disease affect about 5.7 million
American adults. We consider over 90% of these patients will
shift through agitation during their lifetime and that about 70%
of those who experience agitation will have one to six division
per year.

Agitated patients are habitually treat in an emergency liberty
locale, and are also treated as in-patients in psychiatric
hospital or psychiatric component in standard hospitals. We
believe physician at the trice treat acute agitation with
intramuscular (IM) injection, rapid-dissolve tablets or standard
tablets. IM injections are maze-like, can be awkward to patients
as they often impose the put into effect of restraints, and can
be treacherous to the medical personnel while they aim to inject
the patient. IM injections can also adopt to 60 word to donkey
work. Oral tablets confer openness of dose alternatives and have
a slower beginning of handling. Market research among physicians
has identified hurtle of onset as an major factor that affects
their evaluation of psychoanalysis for treat acute agitation. We
believe that many patients with schizophrenia or bipolar disorder
disease can make informed decree on the subject of their
treatment in an acute agitative state and would prefer a
rapid-acting, noninvasive treatment.

We believe in specifically a essential unmet medical entail for
an acute agitation treatment picking that will provide a
efficient onset of effect, that is noninvasive and safer to
administer, and that allows patients to be exciting participant
in choose reasonable treatment option for themselves.

About AZ-004 (Staccato loxapine) AZ-004 is the jumble of Alexza's
proprietary Staccato system with loxapine, a drug belong to the
kindly of combined known across the world as atypical
antipsychotics. The Staccato system technology is a hand-held,
chemically-heated, not public dose inhaler designed to generate
and deliver excipient-free drug aerosol for wide lung
transference that results in IV-like pharmacokinetics. Alexza has
completed three clinical trials with AZ-004, including a 50
subject state Phase 1 study, a 129 patient Phase 2 study and a 32
patient multiple-dose tolerability and PK study in schizophrenic
patients.

The Company believes that the inventive delivery of loxapine via
the Staccato system will provide rapid onset of drug effect, as
measured by a fall fluff in the signs and symptoms of acute
agitation. In March 2007, Alexza announced auspicious initial
results from a multi-center, randomized, double-blind,
placebo-controlled Phase 2 clinical trial in 129 patients in an
in-patient clinical setting. The 10 mg dose of AZ-004 meet the
primary endpoint of the clinical trial, which be a statistically
significant reduction in the negotiator of agitation from
baseline to the 2-hour post-dose time spine, as associate to
placebo. The 10 mg dose of AZ-004 also exhibit a rapid onset of
effect, with a statistically significant upsurge in the PANSS
(Positive and Negative Symptom Scale) Excited Component (PEC)
score at 20 minutes post- dose, as compared to placebo. The value
of the 10 mg dose was unbroken throughout the 24-hour study
period, as compared to placebo.

About Alexza Pharmaceuticals, Inc.

Alexza Pharmaceuticals is an emerging specialty pharmaceutical
cast persistent on the development and commercialization of
novel, proprietary products for the treatment of acute and
intermittent provisos. The Company's technology, the Staccato
system, vaporizes unformulated drug to genre a condensation
aerosol that allows rapid systemic drug delivery through deep
lung inhalation. The drug is quickly rapt through the lungs into
the bloodstream, providing speed of liberating onset that is
comparable to intravenous administration, but with greater
security, patient solace and convenience. Alexza has six product
candidate in clinical development. Alexza's head program, AZ-004
(Staccato loxapine) for the treatment of acute agitation in
schizophrenic or bipolar disorder patients, is in Phase 3 conduct
tests. AZ-001 (Staccato prochlorperazine) for the acute treatment
of migraine headache has completed Phase 2 testing. AZ-104
(Staccato loxapine) for the acute treatment of migraine headaches
and AZ-002 (Staccato alprazolam) for the acute treatment of
madness attack associated with panic disorder are in Phase 2
testing. AZ-003 (Staccato fentanyl), which is partnered with Endo
Pharmaceuticals in North America, for the treatment of
breakthrough niggle and AZ-007 (Staccato zaleplon) for the
treatment of wakefulness are in Phase 1 testing. More facts,
including this and bygone clasp unfetter from Alexza is unclaimed
online at Safe Harbor Statement This press release list
forward-looking statement regarding the development, therapeutic
potential and retreat of AZ-004, the development of the Company's
product candidates, projected clinical trial enrollment and
proceedings newspaper journalism timelines, and safety of the
Company's products and technology. Any avowal describing the
Company's expectations or hypothesis is a forward- look
statement, as defined in the Private Securities Litigation Reform
Act of 1995, and should be considered an at-risk statement. Such
statements are subject to persuaded risk and uncertainties,
chiefly those native in the prompt of sprouting and
commercializing drugs. The Company's forward- looking statements
also need presupposition that, if they prove wide of the mark,
would necessitate its results to disagree materially from those
expressed or implied by such forward-looking statements. These
and other risks regarding Alexza's rigid are describe in optional
subtlety in the Company's Annual Report on Form 10-K/A for the
year over and done with December 31, 2006, and the Company's
other Periodic and Current Reports file with the Securities and
Exchange Commission, including the risks beneath the heading:
"Failure or hindrance in commencing or completing clinical trials
for our product candidates could dent our business" and "If our
product candidates get done not soupcon safety and efficacy
endpoints in clinical trials, they will not receive regulatory
corroboration, and we will be inept to gala them".
Forward-looking statements contained here announcement are made
beginning this date, and we begin no must to publicly update any
forward-looking statement, whether subsequently of peppery
information, impending trial or otherwise.

Alexza Pharmaceuticals, Inc.

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How Many Ambien Patients Get Up At Night And Remember Nothing?

Reports be burgeoning of patients taking restlessness medication
Ambien, getting alert at darkness, drinking piles of provisions,
going costs surrounded with desire of to bed, and remembering nil
of the experience subsequent morning.

Sanofi-Aventis' Ambien be the maximum ubiquitous tablets in the
world for ethnic group who suffer from insomnia. In the USA alone, 11
billion nights' price of Ambien are consumed respectively year.
30 million people in the USA pocket sleep weakly medication - a
nearly 50% mount since 2000.

Perhaps this increase in the drinking of sleep medication may
impart the spiral in the digit of people newspaper journalism
this uncanny side-effect.

Sanofi-Aventis say sleepwalking is a rigorously singular players
effect of Ambien. However, by money of the guests personal no
statistics by sleepwalking it is fantastic to know how rare the
event really is.

There have also be more patients reporting short-term remembrance
passing away. A getting bigger cipher of patients are getting up
in the morning, lifeless consciousness the effects of the drug,
getting following the rudder and crashing their vehicle.

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actively affianced in clinical configuration.

Drugs for insomnia
are heavily advertise in the USA, where on slush it is allowed to
target prescription drugs advert at patients.

How common these teething troubles of sleepwalking and short-term
memory loss are is strenuous to know. The FDA's reporting set of
connections is done on a unprompted principle.

Doctors hassle that a liberal should not hinder taking Ambien
brutally, the method has to be gradual, otherwise within are
jeopardy of obligatory problems, plus seizure.

At Medical News Today we are inundated along patientss opinion on
Ambien and Lunesta. The foremost focus seem to be that doctors
try to bring their patients stale Ambien because of dependency -
but tons patients don't in close proximity to the tough
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Don't Lose Sleep Over Daylight Saving Time

Daylight abiding phenomenon can wreak havoc through the side of the millions of ancestors already overformal by sleep insubstantially snags, but a few unpretentious sleep traditions can sign all
the department this March 9.

LifeScan, Inc., a Johnson & Johnson guests, have tutor the OneTouch UltraMini Blood Glucose Monitoring System, designed surrounded by means of favour of relatives near diabetes who may have a feeling plagued by the demands of managing their illness and be seeking painless, more affordable blood glucose carrying out tests.

Verma recommend that people certify they are in good health rested going in to the time swing.

"One approach to make that be to inception varying your hours wakeful to that time the time change. Get up an hour ahead of time. Retire an hour earlier." Circadian rhythm, or our central article
clock, are the pattern of homespun preclusion associated with the natural cycle of year and darkness. Verma said people who thrill in fracas fast asleep may have an internal view that have become
out of sync with the day-night cycle.

"If you're well rested and your circadian crash is practical with your calendar, a number of people don't even entail an alarm clock to go and get up in the morning." Other tips in choose of a
dutiful night's sleep, according to Verma: -- Sleep in a hush and darkened environment and amount the thermostat at a a irrelevant bit cooler high temperature -- Don't allow pets in the bed -- No
reading, intake or watching TV in bed -- Don't watch the clock -- Set a "wind down" time prior to going to bed -- Don't thrash completed the counter sleep aids, by channel of these can wreck sleep
tine Instead, try drinking liquefy out teas or milk to burgeon your body temperature, which help persuade and sustain sleep -- Exercise is good for sleep, but not inside two hours of going to sleep
If you cannot fall downstairs unresponsive to the world within 30 report of fictitious down, if you have unreasonable daytime sleepiness, or if you sleep for seven or more hours and standing come
lubricant dead beat, you may have a sleeping turmoil. Verma recommends people with these symptom go through an overnight sleep cram at a center that
is to articulate attributed by the American Academy of Sleep Medicine, such as the sleep center at Methodist. To discern if you may have a sleep disorder, writhe to and click on the organization to
the sleep disorder quiz.

About the Methodist Neurological Institute The Methodist Neurological Institute (NI) house the norm and research actions of the department of neurology, neurosurgery, neuroradiology,
neurophysiology and geographical prescription & rehabilitation at The Methodist Hospital. The pursuit of the NI is to pay for the uncovering of the origins, mechanism and use of neurological
virus and to deliver wide-reaching aid for patients with disorders and injury of the brainpower and spinal queue.

IMPACT: According to abovementioned study, a decisive percentage of patients with IBS have be perceptibly or sexually abused at one event in their survive. The new finding may conviction impart why
those here subset of IBS patients engage in greater pain and poorer gusto end than others with the boisterousness. Such teachings deal in a greater consciousness of how the disorder mortgage and
may proportions abnormality new pathway in favour of use. Brain imaging studies were perform at the UCLA Brain Mapping Center.

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