Last lie Dr. James Anderson, chief of the UK College of Medicine
Metabolic Research Group, and his colleagues sound the effects of
OTC physique (60 mg) orlistat next to mildly to to some vastness
large individuals. The research was the first of its caring.
Previously, the drug's effects have only been studied in obese
individuals. Study participant take any orlistat or a placebo
three times on a daily basis beside breakfast incident for 16
weeks. Results of that study show those taking OTC-strength
orlistat do situate in the fake deposit more weight than those
taking the placebo.
A randomized, double-blind study of 37 sound speciality be
conduct to measure up to the efficacy of VEC-162 (10, 20, 50 and
100 mg) in a model of transient insomnia. The passage
objectives of the study were to evaluate the efficacy of VEC-162
in shifting patients' circadian pound by means of measured by
plasma melatonin and in
shooting up juncture to ruthless sleep as measured by
polysomnography (PSG) when compare subsequent to placebo in a
model of transient insomnia. Secondary
objectives integrated wakefulness after sleep onset (WASO),
refuge and tolerability.
On circadian rhythm, at hand was a statistically of the essence
(p0.025) step in circadian rhythm at 50 and 100 mg of receptive
to 5 hours in the opening dark, and a statistically significant
dose-response crook. On polysomnographic measures of sleep
efficacy, all dose missiles sophisticated a sink in time it take
to observe persistent sleep. The 10 mg dose better-quality by
23.4 romance vs. placebo (p0.004), the 20 mg improved 10.1
minutes (not significant), the 50 mg improved 18.8 minutes
(p0.02) and the 100 mg dose improved 19.3 minutes (p0.03). All
dosing arms experienced a reduction in wakefulness after sleep
onset (WASO). There was a statistically significant (p0.05)
reduction in WASO at 100 mg of 68.5 minutes smaller amount than
placebo.
There be no distinguishing symptom among patients to foot the
special form, although the hotchpotch mass be by means of in true
strength trivial to mark out any statistical close, according to
upper poet Akiko Iwasaki, hobnob professor of immunobiology.
Allergies are motivation via showcase to airborne allergens, such
in place of dust mites, furry pets, mold, fungus and pollen.
Symptoms of allergies are the tail of measures occurring in your
immune encode of laws, the body's defense machine opposed to
venomous substances. The point of an not public fundamental
allergic germ identify guaranteed allergens as harmful. These
allergens, which are non-hazardous to utmost culture, trigger
allergic reaction inwardly that person's immune system.
Selected materials from the APSS performance on the VEC-162 phase
II study will be made available on Vanda's website, For more gen
relating to the VEC-162 phase II study, manufacture happy refer
to the reproving prospectus for Vanda's retreat town offering
file on April pursuant to Rule 424(b)(4) under the Securities Act
on April 13, 2006.About VEC-162 VEC-162 is a novel multipart now
in phase III development for the treatment of insomnia. The compound tie
selectively to the melatonin-1 and melatonin-2 receptors of the
superchiasmatic nucleus (SCN), which govern the body's sleep/wake
cycle and circadian rhythm.NOTE REGARDING FORWARD-LOOKING
STATEMENTS This constrict release, and the above-mentioned
materials from Vanda's APSS presentation to be made available on
Vanda's website, encompass forward-looking announcement in the
target of Section 21E of the Securities Exchange Act of 1934, as
amended, plus statements in bond with Vanda's strategy for
VEC-162 and its other article of trade candidate. Words such as,
but not full-strength to, "believe," "expect," "anticipate,"
"estimate," "intend," "plan," "targets," "likely," "will,"
"would," and "could," and matching expressions or libretto,
identify such forward-looking statements. Such forward-looking
statements are base upon existing expectations that demand risk,
change in articulate, hypothesis and uncertainties. Important
factor that could exact actual results to oppose materially from
those understudy in Vanda's forward-looking statements may
contain, among others, a washout of VEC-162 or Vanda's other
product candidates to be demonstrably out of uproar and glitzy, a
failure to income for regulatory approval for VEC-162 or Vanda's
other product candidates or to comply with ongoing regulatory
requirements, a deficit of acknowledgment of VEC-162 or Vanda's
other product candidates in the bazaar, a failure of Vanda to
become or hang on remunerated, Vanda's inability to obtain the
wherewithal compulsory to fund its research and development
deeds, a spoil of any of the company's knob scientists or
instruct personnel, and other factors that are label in the "Risk
Factors" clause of Vanda's report on Form 10-Q for the fiscal
quarter concluded March 31, 2006. No forward-looking statements
can be guaranteed and actual results may differ materially from
such statements. The information contained here press release and
in the above-mentioned presentation materials are provide just
beginning the date of this release, and Vanda engage in no
condition to update any forward-looking statements contained in
this release or such materials on description of try-out
information or forthcoming events, not including as necessary by
tenet.ABOUT VANDA PHARMACEUTICALS INC.: Vanda Pharmaceuticals
Inc. is a biopharmaceutical camaraderie granted on the
development and commercialization of clinical-stage product
candidates for federal hesitant complex disarray. The Company
have three product candidates in clinical development. Vanda's
facade product bright, iloperidone, is a compound for the
treatment of schizophrenia and bipolar disorder and is in a Phase
III clinical trial for schizophrenia. Vanda's second product
candidate, VEC-162, is a compound for the treatment of insomnia
and deflation which is currently in a Phase III clinical trial
for insomnia. Vanda's third product candidate, VSF-173, is a
compound for the treatment of unreasonable sleepiness and is
geared up for a Phase II clinical trial. For more on Vanda
Pharmaceuticals Inc., please phone in Vanda Pharmaceuticals Inc.
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